Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Rational Dosage Regimen: Maintenance Dose and Loading Dose

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...

Dosage Regimens: Designs and Approaches

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neovascular age-related macular degeneration patient questions for their eye care providers and preferences for education.

Optometry and vision science : official publication of the American Academy of Optometry·2026

Same author

Feasibility and pilot outcomes of a novel training to help clinicians counsel adolescents about online contraceptive information.

Digital health·2026

Same author

Clinician Recommendations for Discussing Online Health Information With Adolescents: A Qualitative Study.

Journal of primary care & community health·2026

Same author

Occupational Therapy for Excess Body Weight in Primary Care Settings.

OTJR : occupation, participation and health·2026

Same author

How Often do Youth ask Their Providers the Questions They Checked on an Attention-Deficit Hyperactivity Disorder Question Prompt List?

Journal of developmental and behavioral pediatrics : JDBP·2026

Same author

Contraception-Related Posts from Adolescents, Young Adults, and Caregivers on Reddit: A Qualitative Content Analysis.

Journal of pediatric and adolescent gynecology·2026

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Prescriber continuity and medication adherence for complex patients.

Richard A Hansen¹, Corrine I Voils², Joel F Farley³

¹Harrison School of Pharmacy Auburn University, AL, USA.

The Annals of Pharmacotherapy

|January 1, 2015

Summary

Minimizing the number of healthcare providers may improve medication adherence for patients with hypertension and dyslipidemia. Managing complex patients with multiple cardiometabolic conditions requires careful coordination of care.

Keywords:

adherence comorbidity complex patient multimorbidity prescriber provider veterans

More Related Videos

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Related Experiment Videos

Last Updated: Apr 19, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Area of Science:

Cardiology
Endocrinology
Pharmacology

Background:

Medication adherence is crucial for managing cardiometabolic conditions like diabetes, hypertension, and dyslipidemia.
Patients with multiple conditions and prescribers face higher risks of nonadherence.

Purpose of the Study:

To investigate the link between the number of prescribers, the number of cardiometabolic conditions, and oral medication refill adherence.
To analyze how these factors impact adherence in a veteran population.

Main Methods:

Retrospective cohort study of 7933 veterans with 1-4 cardiometabolic conditions.
Refill adherence measured using continuous multiple-interval gap (CMG) for diabetes, hypertension, and dyslipidemia medications.
Logistic regression models controlled for demographics, comorbidities, and drug classes.

Main Results:

Lower antihypertensive adherence observed with ≥4 prescribers (OR=0.69).
Lower antidyslipidemia adherence seen with 3 or ≥4 prescribers (OR=0.80, OR=0.77).
Improved antidyslipidemia adherence correlated with ≥3 conditions (OR=1.31); no significant predictors for diabetes medication adherence.

Conclusions:

Reducing the number of prescribers may enhance medication refill adherence for hypertension and dyslipidemia.
Effective care management for complex patients with multiple cardiometabolic conditions remains a challenge.