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[Effect of benazepril on cardiac function in Chinese patients with chronic heart failure: a meta-analysis of

Xiaowei Yan1, Dingli Xu, Jun Huang2

  • 1Email: xswy_pumc@163.com.

Zhonghua Yi Xue Za Zhi
|January 1, 2015
PubMed

Insights

Benazepril effectively treats Chinese patients with chronic systolic heart failure, improving key cardiac metrics. This ACE inhibitor is safe, with cough being the most common side effect.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Research

Background:

  • Chronic systolic heart failure (CSHF) poses a significant health burden, particularly in Asian populations.
  • Angiotensin-converting enzyme inhibitors (ACEIs) are a cornerstone therapy for heart failure, but their efficacy in Chinese patients requires specific evaluation.

Purpose of the Study:

  • To assess the efficacy and tolerability of benazepril in Chinese individuals diagnosed with CSHF.
  • To compare benazepril's effects with other treatments, including angiotensin II receptor blockers (ARBs).

Main Methods:

  • A systematic literature search was conducted across major databases (Cochrane, PubMed, EMbase, CBM, CNKI) from 1989 to 2010.
  • Randomized controlled trials (RCTs) meeting predefined inclusion/exclusion criteria were independently identified by two investigators.
  • Statistical analysis was performed using Stata 11 software.

Main Results:

  • Fifteen RCTs involving 1,355 Chinese patients with CSHF were analyzed.
  • Benazepril monotherapy (5-40 mg/day) demonstrated significant improvements in left ventricular ejection fraction (LVEF), cardiac output, and left ventricular end-diastolic diameter (LVEDD) compared to baseline.
  • Benazepril showed comparable efficacy to ARBs in improving LVEF, reducing LVEDD, and enhancing cardiac output. Combination therapy with benazepril and ARB was superior to ARB monotherapy in reducing LVEDD.

Conclusions:

  • Benazepril is an effective and safe therapeutic option for managing chronic systolic heart failure in Chinese patients.
  • The most frequently reported side effect was cough (11.6%), with other adverse events being infrequent.
Abstract

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