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Altered heart rate variability depend on the characteristics of coronary lesions in stable angina pectoris

Jun Feng1, Ailing Wang, Chao Gao

  • 1Department of Cardiology, the Affiliated Hefei Hospital of Anhui Medical University (The 2nd People's Hospital of Hefei); Hefei Anhui Province-China. Fengjun0071@sina.com.

Anatolian Journal of Cardiology
|January 1, 2015
PubMed

Insights

Heart rate variability (HRV) indicates autonomic dysfunction in stable angina patients. Lower HRV metrics correlate with coronary artery damage severity and extent, suggesting HRV

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Medical Diagnostics

Background:

  • Cardiac autonomic nerve dysfunction is a risk factor for coronary atherosclerotic heart disease.
  • Heart rate variability (HRV) is a key indicator for assessing autonomic nervous system function.
  • The relationship between coronary artery damage and autonomic dysfunction in stable angina needs further elucidation.

Purpose of the Study:

  • To investigate the correlation between coronary artery damage and autonomic nervous system dysfunction using HRV in stable angina patients.
  • To evaluate if HRV can predict the severity and extent of coronary artery disease.

Main Methods:

  • 236 patients with stable angina were categorized by Gensini score (GS≤32 [GS1] and GS>32 [GS2]).
  • Subgroups were formed based on lesion location and number of diseased coronary arteries.
  • 24-hour ambulatory electrocardiograms were analyzed for time-domain HRV parameters (SDNN, SDANN, SDNNind, RMSSD, PNN50) in patients and 86 controls.

Main Results:

  • Patients with stable angina (GS1 and GS2) exhibited significantly lower HRV compared to controls.
  • Higher Gensini scores (GS2) were associated with further reductions in HRV parameters (SDNN, SDANN, SDNNind, RMSSD, PNN50) compared to GS1.
  • Increased number and specific locations of coronary artery lesions correlated with diminished HRV metrics.

Conclusions:

  • HRV is a valuable non-invasive tool for assessing autonomic dysfunction in stable angina.
  • Reduced HRV parameters are significantly associated with the severity and extent of coronary artery damage.
  • HRV may play a crucial role in estimating the correlation between coronary artery damage and autonomic nervous system dysfunction.
Abstract

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