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Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia
Qiong Luo1, Bin Lei2, Shuguang Liu2
1Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Oncology, Leiyang People's Hospital Leiyang City, Hunan Province, China.
Unlabelled:
objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia.
Methods:
PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).
Results:
PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).
Conclusion:
PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.
