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Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Ribosome Profiling02:24

Ribosome Profiling

4.4K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Related Experiment Video

Updated: Apr 19, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

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The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling.

Masato Habuka1, Linn Fagerberg2, Björn M Hallström2

  • 1School of Biotechnology, Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Department of Structural Pathology, Institute of Nephrology, Medical and Dental School, Niigata University, Asahimachi-dori Niigata, Japan.

Plos One
|January 1, 2015
PubMed
Summary
This summary is machine-generated.

Researchers mapped the kidney

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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Related Experiment Videos

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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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Area of Science:

  • Molecular biology
  • Genomics
  • Proteomics

Background:

  • Understanding kidney function and disease requires detailed knowledge of its molecular components.
  • Previous studies have not comprehensively characterized the kidney's specific molecular makeup across its various compartments.

Purpose of the Study:

  • To create a comprehensive map of the kidney-specific transcriptome and proteome.
  • To identify genes and proteins with elevated expression in specific kidney subcompartments.

Main Methods:

  • Comparative transcriptomic analysis across all major human organs and tissues.
  • Kidney tissue microarray-based immunohistochemistry to determine protein localization.

Main Results:

  • Identified nearly 400 genes with elevated kidney expression, categorized as tissue enriched, group enriched, or tissue enhanced.
  • Localized specific proteins to glomeruli, proximal tubules, distal tubules, and collecting ducts.
  • Discovered several novel kidney-elevated transcripts and proteins.

Conclusions:

  • This study provides a detailed resource of the kidney-specific transcriptome and proteome.
  • Facilitates future research into kidney biology and disease mechanisms.
  • A valuable tool for basic and clinical researchers studying renal function.