Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

582
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
582
Cell Lines01:16

Cell Lines

11.3K
A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
11.3K
Ethics in Research01:56

Ethics in Research

26.3K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
26.3K
Preclinical Development: Overview01:28

Preclinical Development: Overview

6.6K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.6K
Improving Translational Accuracy02:07

Improving Translational Accuracy

15.7K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
15.7K
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

285
Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
285

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ending publication bias: A values-based approach to surface null and negative results.

PLoS biology·2025
Same author

Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.

Cancer discovery·2023
Same author

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers.

Science translational medicine·2021
Same author

Categorizing the characteristics of human carcinogens: a need for specificity.

Archives of toxicology·2021
Same author

Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol.

F1000Research·2020
Same author

The Antibody Society's antibody validation webinar series.

mAbs·2020

Related Experiment Video

Updated: Apr 19, 2026

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

5.0K

Reproducibility in science: improving the standard for basic and preclinical research.

C Glenn Begley1, John P A Ioannidis2

  • 1From the TetraLogic Pharmaceuticals Corporation, Malvern, PA; and Departments of Medicine and Health Research and Policy, Stanford University School of Medicine, Department of Statistics, Stanford University School of Humanities and Sciences, and Meta-Research Innovation Center at Stanford (METRICS), CA.

Circulation Research
|January 2, 2015
PubMed
Summary

The reproducibility crisis in biomedical research stems from poor scientific practices and publishing pressures. Addressing this requires multifaceted solutions to improve the reliability of scientific discoveries.

Keywords:
fundingjournalsresearch integrityuniversities

More Related Videos

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
04:50

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research

Published on: August 4, 2023

1.8K
Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis
08:52

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Published on: November 17, 2021

2.9K

Related Experiment Videos

Last Updated: Apr 19, 2026

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

5.0K
Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
04:50

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research

Published on: August 4, 2023

1.8K
Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis
08:52

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Published on: November 17, 2021

2.9K

Area of Science:

  • Biomedical Research
  • Scientific Integrity

Background:

  • The rapid increase in data and publications in biomedical research is unprecedented.
  • However, a significant portion of these discoveries may lack long-term validity.
  • This raises concerns about the reliability of current scientific knowledge.

Purpose of the Study:

  • To review the reproducibility challenges in basic and preclinical biomedical research.
  • To highlight the complexities contributing to the reproducibility crisis.
  • To discuss potential strategies for enhancing research quality and reproducibility.

Main Methods:

  • Literature review of reproducibility issues in biomedical research.
  • Analysis of factors contributing to the 'publish or perish' culture.
  • Exploration of solutions to improve scientific rigor.

Main Results:

  • The reproducibility crisis is a complex issue with multiple contributing factors.
  • Failures in good scientific practice and intense publication pressure are key drivers.
  • No single solution can resolve this multifaceted problem.

Conclusions:

  • Improving reproducibility in biomedical research is critical for scientific advancement.
  • A collaborative, multistakeholder approach is needed to implement effective solutions.
  • Enhancing research quality will ensure a more robust foundation for future discoveries.