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High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
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Published on: July 25, 2014

A molecular modelling study of the interaction of noradrenaline with the beta 2-adrenergic receptor

T J Mitchell1, M S Tute, G A Webb

  • 1Department of Chemistry, University of Surrey, Guildford, U.K.

Journal of Computer-Aided Molecular Design
|September 1, 1989
PubMed

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Postganglionic sympathetic fibers (except those supplying the sweat glands) releasing noradrenaline or norepinephrine are called noradrenergic or adrenergic neurons. Noradrenaline, dopamine, adrenaline, or epinephrine are collectively called "catecholamines" as they contain a catechol moiety and an amine side chain. The five stages of neurotransmitter release involve their synthesis, storage, release, reuptake and metabolism.
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Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
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Adrenergic Receptors: β Subtype

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