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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Assessment of the Cardiovascular System III: Palpation01:27

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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Related Experiment Video

Updated: Apr 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

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[Pemetrexed-induced scleroderma-like changes in the lower legs].

C Corbaux1, J Marie2, J-P Meraud2

  • 1Service de dermatologie, centre hospitalier universitaire Haut-Lévêque, 1, avenue Magellan, 33600 Pessac, France.

Annales De Dermatologie Et De Venereologie
|January 3, 2015
PubMed
Summary
This summary is machine-generated.

Pemetrexed, used for lung cancer and mesothelioma, can cause a rare, unrecognized skin toxicity resembling scleroderma. Early recognition and folate supplementation may help manage this pemetrexed side effect.

Keywords:
Anti-folatesCutaneous toxicityErysipelas-likePemetrexedPseudo-érysipèleSclerodermaSclérœdèmeToxicité cutanéeÉrysipèle

Related Experiment Videos

Last Updated: Apr 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Pemetrexed is a key antifolate chemotherapy agent for malignant pleural mesothelioma and non-small cell lung cancer (NSCLC).
  • This report details two cases of an emerging, previously unrecognized toxicity associated with pemetrexed treatment.

Observation:

  • Two patients with metastatic NSCLC developed lower extremity edema and induration after pemetrexed therapy.
  • Initial symptoms were misdiagnosed as erysipelas due to painful, erythematous, and violaceous plaques, despite the absence of fever.

Findings:

  • Pemetrexed discontinuation led to slow improvement, but scleroderma-like changes persisted.
  • The severity of this cutaneous toxicity may correlate with a patient's folate status.

Implications:

  • Recognizing this scleroderma-like toxicity is crucial to avoid diagnostic delays and inappropriate treatments.
  • Folate and vitamin B12 supplementation, potentially with dexamethasone, may mitigate this pemetrexed-induced side effect.
  • Taxanes did not exacerbate this toxicity, suggesting differential mechanisms compared to other scleroderma-inducing agents.