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Fibrinogen alpha and beta gene polymorphisms in pediatric stroke--case-control and family based study
I Kopyta1, P Niemiec2, A Balcerzyk2
1School of Medicine in Katowice, Medical University of Silesia, Department of Paediatrics and Developmental Age Neurology, Chair of Paediatrics, Medykow Str 16, 40-752 Katowice, Poland.
Summary
Genetic variations in fibrinogen genes (FGA and FGB) are not associated with childhood arterial ischemic stroke. This study found no significant link between specific FGA and FGB gene polymorphisms and stroke risk in children.
Area of Science:
- Genetics
- Pediatric Neurology
- Cardiovascular Research
Background:
- Childhood ischemic stroke is a serious condition with complex etiology.
- The role of specific gene polymorphisms in fibrinogen (FGA and FGB) in pediatric stroke remains unclear.
- Previous data on these polymorphisms and childhood arterial ischemic stroke are limited.
Purpose of the Study:
- To investigate the association between the FGA Thr312Ala and FGB -455G>A gene polymorphisms and childhood arterial ischemic stroke.
- To evaluate the potential contribution of these genetic factors to stroke risk in pediatric patients.
- To clarify the existing insufficient data on this topic.
Main Methods:
- Case-control study involving 85 children with ischemic stroke, 146 parents, and 159 controls.
- Genotyping of FGA Thr312Ala and FGB -455G>A polymorphisms using restriction fragment length polymorphism.
- Utilized both case-control and family-based transmission-disequilibrium test (TDT) designs for analysis.
Main Results:
- The transmission-disequilibrium test showed a non-significant tendency towards higher transmission of the 312Ala allele (FGA) and -455A allele (FGB).
- Allele and genotype frequencies for both FGA and FGB polymorphisms did not differ significantly between stroke cases and controls.
- No additive or synergistic effects were observed between the FGA and FGB gene polymorphisms.
Conclusions:
- The studied FGA and FGB gene polymorphisms are not significantly associated with arterial ischemic stroke in children.
- Current evidence suggests these specific genetic variations do not contribute to the risk of stroke in the pediatric population.
- Further research may be needed to explore other genetic or environmental factors influencing childhood ischemic stroke.
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