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Updated: Apr 19, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Medical therapies in pituitary adenomas: Current rationale for the use and future perspectives
Thomas Cuny1, Anne Barlier2, Richard Feelders3
1Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands; CRN2M, UMR 7286 CNRS, Aix-Marseille University, 13344 Marseille cedex 15, France; Department of Endocrinology, University Hospital of Nancy Brabois, 54500 Vandœuvre-Les-Nancy, France.
Abstract:
Pituitary adenomas (PA) represent in the majority of cases, benign tumors whose treatment currently associate surgery, medical therapies and radiotherapy in a multidisciplinary approach. While trans-sphenoidal surgery remains, except for prolactin-secreting adenomas, the first-line treatment of PA, it can considerably be hampered by the existence of an invasive and/or aggressive tumor for which medical therapies are often requested. In this review, we extensively discuss, both at molecular and clinical levels, the medical therapies currently used and in development in the different phenotypes of pituitary adenomas.
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