BODIPY-based fluorescent thermometer as a lysosome-targetable probe: how the oligo(ethylene glycols) compete
Hua Wang1, Yongquan Wu, Yanlin Shi
1Department of Polymer Materials, Shanghai University, Nanchen Road 333, 200444, Shanghai (P.R. China).
Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 6, 2015
Abstract:
A novel BODIPY-based fluorescent thermometer, which shows a lysosome-targeting property, was successfully prepared. Due to the electron-donating ability of the oligo(ethylene glycols), the photoinduced electron-transfer pathway from morpholine to BODIPY dye is blocked. The fluorescence of the thermometer quenched by intramolecular rotation at room temperature was progressively enhanced during heating due to the increased microviscosity around the fluorophore.
