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Updated: Apr 19, 2026

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
Published on: January 3, 2011
Monitoring corneal hydration with a mid-infrared (IR) laser
Abhijeet Joshi1, David B Bennett2, Oscar M Stafsudd1
1Department of Electrical Engineering, University of California, Los Angeles, CA, USA.
Abstract:
A mid-infrared (IR) source at ∼ 3 μm radiation is used as a probe to measure hydration in porcine cornea. Since the Er(3+):YAG emission targets vibrational modes (around 3300 cm(-1)) in the H2O molecule, it is highly sensitive to changes in water content in the first ∼ 10 μm of the corneal tissue.
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