Related Experiment Video
Updated: Apr 19, 2026
A Tablet-Based Curriculum-Based Measurement Protocol for Kindergarten Writing
Published on: February 7, 2025
A workshop report on the development of the Cow's Milk-related Symptom Score awareness tool for young children
Yvan Vandenplas1, Christophe Dupont, Philippe Eigenmann
1UZ Brussel, Free University of Brussels, Brussels, Belgium.
Insights
The Cow's Milk-related Symptom Score (CoMiSS) is a new tool to help primary healthcare providers identify symptoms related to cow's milk ingestion. It serves as an awareness aid for cow's milk-related symptoms in children.
Area of Science:
- Pediatric Gastroenterology
- Allergology
- Clinical Assessment Tools
Background:
- Cow's milk protein is a common allergen in infants and children.
- Accurate identification of cow's milk-related symptoms is crucial for timely intervention.
- Existing diagnostic methods may not be readily accessible in primary care settings.
Framework:
- The Cow's Milk-related Symptom Score (CoMiSS) was developed by experts in pediatric gastrointestinal and atopic diseases.
- CoMiSS integrates general, dermatological, gastrointestinal, and respiratory symptoms.
- It is designed as an awareness and evaluation tool, not a diagnostic test.
Implementation:
- The score was developed based on a literature review at a workshop in Brussels, September 2014.
- It is intended for use by primary healthcare providers to aid in recognizing potential cow's milk-related issues.
- CoMiSS can quantify symptom evolution during treatment but does not replace formal allergy testing.
Implications:
- CoMiSS offers a simple, rapid method for primary care clinicians to assess cow's milk-related symptoms.
- It can improve early recognition and management of non-IgE mediated cow's milk protein allergy.
- Further validation through prospective studies is recommended to confirm its clinical utility.
Unlabelled:
Clinicians with expertise in managing children with gastrointestinal problems and/or atopic diseases attended a workshop in Brussels in September 2014 to review the literature and determine whether a clinical score derived from symptoms associated with the ingestion of cow's milk proteins could help primary healthcare providers. The Cow's Milk-related Symptom Score (CoMiSS), which considers general manifestations, dermatological, gastrointestinal and respiratory symptoms, was developed as an awareness tool for cow's milk-related symptoms. It can also be used to evaluate and quantify the evolution of symptoms during therapeutic interventions, but does not diagnose cow's milk protein allergy and does not replace a food challenge. Its usefulness needs to be evaluated by a prospective randomised study.
Conclusion:
The CoMiSS provides primary healthcare clinicians with a simple, fast and easy-to-use awareness tool for cow's milk-related symptoms.
