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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
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Technical note: Rapid calculation of genomic evaluations for new animals
G R Wiggans1, P M VanRaden1, T A Cooper1
1Animal Genomics and Improvement Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705-2350.
Journal of Dairy Science
|January 6, 2015
Summary
A new method provides daily or weekly preliminary genomic evaluations, enabling faster decisions for producers. This approach improves efficiency for genotyping labs by smoothing monthly workloads.
Area of Science:
- Animal Breeding and Genetics
- Genomic Evaluation Methods
- Quantitative Genetics
Background:
- Official genomic evaluations are typically released monthly.
- Producers require timely genetic information for decision-making.
- Genotyping laboratories face workload peaks at evaluation release dates.
Purpose of the Study:
- To develop a method for generating preliminary genomic evaluations.
- To enable daily or weekly genomic evaluations before official monthly releases.
- To assess the accuracy and benefits of preliminary genomic evaluations.
Main Methods:
- Developed a method using newly genotyped animals and SNP effects from previous evaluations.
- Minimized computation by omitting reliability and inbreeding calculations.
- Utilized fixed weights for combining genomic and traditional data.
Main Results:
- Correlations between preliminary and official evaluations exceeded 0.99 for most Holstein traits.
- Lower correlations were observed in breeds with smaller population sizes.
- The method allows earlier access to genomic data.
Conclusions:
- Preliminary genomic evaluations can be accurately generated weekly or daily.
- This method benefits producers through earlier culling decisions.
- Workloads for genotyping labs become more uniform throughout the month.
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