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Arterial stiffness in diabetes mellitus
Stuart B Prenner1, Julio A Chirinos2
1University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, 6 Penn Tower, Philadelphia, PA 19104, USA.
Atherosclerosis
|January 6, 2015
Summary
Arterial stiffness, a key factor in aging and diabetes mellitus (DM), accelerates DM complications. Early detection in pre-diabetes and metabolic syndrome is crucial for managing cardiovascular risk.
Area of Science:
- Cardiovascular Health
- Endocrinology
- Aging Research
Background:
- Arterial stiffness is an age-related condition linked to diabetes mellitus (DM) and increased mortality.
- Existing literature on arterial stiffness in DM patients lacks a comprehensive review.
Purpose of the Study:
- To systematically review current understanding of arterial stiffness in DM.
- To explore the relationship between arterial stiffness and DM complications.
- To investigate arterial stiffness in pre-diabetic and metabolic syndrome populations.
Main Methods:
- Systematic literature search strategy employed.
- Key studies reviewed to summarize findings on arterial stiffness and DM.
Main Results:
- Arterial stiffness correlates with DM complications like nephropathy, retinopathy, and neuropathy.
- Elevated arterial stiffness is observed in pre-diabetes and metabolic syndrome, preceding overt DM.
- Arterial stiffness may predict DM onset.
Conclusions:
- Arterial stiffness is closely linked to DM progression and complications.
- Further research is needed on the role of arterial stiffness in DM pathogenesis and the efficacy of related interventions.
- Potential mechanisms include advanced glycation endproducts and nitric oxide dysregulation.
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