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Intussusception in Australia: epidemiology prior to the introduction of rotavirus vaccine

Retno Palupi-Baroto1, Katherine J Lee, John B Carlin

  • 1School of Population Health, University of Melbourne, Victoria; Faculty of Medicine, Universitas Gadjah Mada, Indonesia.

Australian and New Zealand Journal of Public Health
|January 7, 2015
PubMed

Insights

The incidence of intussusception in Australian children under two years old was 5.4 per 10,000 child-years before rotavirus vaccines were introduced. Age was a key factor influencing hospital stay and surgical intervention needs.

Area of Science:

  • Pediatric Gastroenterology
  • Vaccinology
  • Epidemiology

Background:

  • Intussusception is a significant cause of intestinal obstruction in infants.
  • Rotavirus vaccines have been associated with changes in intussusception incidence globally.
  • Understanding pre-vaccine incidence is crucial for post-vaccine surveillance.

Purpose of the Study:

  • To determine the incidence rate of intussusception in Australian children under 24 months before rotavirus vaccine introduction.
  • To analyze clinical outcomes and associated patient characteristics.
  • To establish a baseline for future rotavirus vaccine impact assessment.

Main Methods:

  • Utilized Australian national hospital discharge data (July 2000-June 2006).
  • Employed Australian Bureau of Statistics data for population estimates.
  • Applied logistic regression to explore associations between patient factors (age, sex, ethnicity) and outcomes (prolonged hospital stay, surgery).

Main Results:

  • Overall incidence rate was 5.4 per 10,000 child-years (95% CI 5.17-5.70).
  • A statistically significant declining trend in incidence was observed over the study period (p<0.001).
  • Patient age demonstrated a strong association with both length of hospital stay and the requirement for surgical intervention.

Conclusions:

  • Provides essential pre-rotavirus vaccine incidence data for Australian children under 24 months.
  • Establishes a critical benchmark for monitoring intussusception rates post-vaccine implementation.
  • Highlights the importance of age as a predictor for intussusception severity and management.
Abstract

Keywords:
childrenepidemiologyintussusceptionrotavirus vaccine

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