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Cell therapy in shock: a reasonable prospect or a lost cause?
1Department of Emergency and Critical Care Medicine, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain.
Resuscitation
|January 1, 1989
Summary
Body insults trigger shock, leading to widespread biological disruption and organ failure without treatment. This review details cellular disturbances in hypovolemic and septic shock and future therapies.
Area of Science:
- Physiology
- Biochemistry
- Pathology
Background:
- Insults to the body initiate a cascade of physiological and biochemical changes culminating in shock.
- Without timely intervention, shock leads to systemic disruption of biological mechanisms.
- Persistent cellular and subcellular disturbances are key factors in the development of multiple organ failure.
Purpose of the Study:
- To review cellular and subcellular disturbances associated with the shock syndrome.
- To outline current understanding of the mechanisms driving these disturbances, focusing on hypovolemic and septic shock.
- To discuss current and future therapeutic implications for managing shock and its consequences.
Main Methods:
- Literature review of cellular and subcellular changes in shock.
- Analysis of current research on the mechanisms of hypovolemic and septic shock.
- Synthesis of information on therapeutic strategies.
Main Results:
- Shock involves complex cellular and subcellular disturbances.
- Hypovolemic and septic shock share common pathways but have distinct features.
- Understanding these mechanisms is crucial for effective treatment.
Conclusions:
- Cellular and subcellular disturbances are central to shock pathophysiology and organ failure.
- Further research into shock mechanisms can guide the development of novel therapies.
- Effective management of shock requires addressing its underlying cellular derangements.