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Preparation of a Blood Culture Pellet for Rapid Bacterial Identification and Antibiotic Susceptibility Testing
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Profile of fatal Streptococcal bacteraemia at a tertiary care Indian hospital

P Punia1, N Bhardwaj, P Mathur

  • 1Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center Trauma Centre, All India Institutes of Medical Sciences, Delhi - 110 029, India.

Indian Journal of Medical Microbiology
|January 7, 2015
PubMed

Insights

Rapidly fatal Group A, F, and G Streptococcus bacteraemia occurred in five patients despite penicillin sensitivity. Prompt species identification and antimicrobial susceptibility testing are crucial for timely intervention in suspected beta-hemolytic Streptococcus infections.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Pathology

Background:

  • Streptococcus pyogenes is a pathogen causing a spectrum of diseases.
  • Bacteraemia, a serious bloodstream infection, can arise from various Streptococcus groups.

Observation:

  • Five cases of fatal bacteraemia due to beta-hemolytic Streptococci were observed.
  • Three cases involved Group G Streptococcus, with one each of Group A and Group F Streptococcus.
  • Rapid mortality was noted despite all isolates being sensitive to penicillin.

Findings:

  • Group G Streptococcus was the most frequent cause of fatal bacteraemia in this series.
  • Penicillin sensitivity did not prevent rapid progression to death in these cases.
  • Timely intervention is critical for managing severe streptococcal infections.

Implications:

  • Accurate species-level identification of beta-hemolytic Streptococci is essential for effective treatment.
  • Antimicrobial susceptibility testing should be routinely performed for all beta-hemolytic Streptococcus isolates.
  • Early clinical suspicion and prompt management are vital to improve outcomes in severe streptococcal bacteraemia.

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