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Beyond the Gut: Genome-Characterised Salmonella Kentucky ST198 Urinary Tract Infection
Mahuya Roy1, Inderjit Singh1, Dhananjay Kumar1
1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Abstract:
Non-typhoidal Salmonella urinary tract infections (UTIs) are rare and may be linked to immunosuppression, chronic illnesses, or structural urinary tract abnormalities. Salmonella enterica serovar Kentucky (ST198) is a globally disseminated lineage associated with fluoroquinolone resistance and the acquisition of additional antimicrobial resistance (AMR) determinants. This is the first Indian case report of a rare UTI caused by Salmonella Kentucky ST198, resistant to both fluoroquinolones and extended-spectrum cephalosporins. This report emphasises the value of whole-genome sequencing (WGS) for serovar-level characterisation and resistance-gene discovery in uncommon Salmonella isolates, as well as the importance of off-label azithromycin use for treating UTI for a favourable outcome.
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