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Updated: Apr 19, 2026

Integration Free Derivation of Human Induced Pluripotent Stem Cells Using Laminin 521 Matrix
Published on: July 7, 2017
The DISCUSS Project: Revised Points to Consider for the Derivation of Induced Pluripotent Stem Cell Lines From
Geoffrey P Lomax1, Sara Chandros Hull2, Rosario Isasi3
1California Institute for Regenerative Medicine, San Francisco, California, USA; glomax@cirm.ca.gov glomax@lmi.net.
Abstract:
Human somatic cell reprogramming is a leading technology for accelerating disease modeling and drug discovery. The Deriving Induced Stem Cells Using Stored Specimens (DISCUSS) project is a consensus-building initiative designed to consider how human somatic cells obtained under general biomedical research protocols can be used in induced pluripotent stem cell (iPSC) derivation. We previously published a draft list of points to consider for the use of previously collected specimens in iPSC research and then initiated a structured feedback and comment process. Here, we present a summary of this feedback and revised list of points to consider.
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