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Prevalence of celiac disease in Turkish children with idiopathic epilepsy

Sedat Işikay1, Şamil Hizli2, Kutluhan Yilmaz1

  • 1Department of Pediatric Neurology, Gaziantep Children's Hospital.

Iranian Journal of Pediatrics
|January 7, 2015
PubMed

Insights

Celiac disease (CD) prevalence is higher in Turkish children with epilepsy, particularly those with childhood partial epilepsy with occipital paroxysms (CPEO). This suggests a potential link between epilepsy and CD that warrants clinical attention.

Area of Science:

  • Pediatric Neurology
  • Gastroenterology
  • Immunology

Background:

  • Idiopathic epilepsy is a common neurological disorder in children.
  • Celiac disease (CD) is an autoimmune disorder triggered by gluten.
  • The association between epilepsy and CD is not fully understood.

Purpose of the Study:

  • To investigate the prevalence of celiac disease (CD) in Turkish children diagnosed with idiopathic epilepsy.
  • To explore the association between CD and different types of epilepsy, including childhood partial epilepsy with occipital paroxysms (CPEO).

Main Methods:

  • A cohort of 214 children with idiopathic epilepsy and 166 healthy controls were screened for CD using IgA anti-tissue transglutaminase antibodies.
  • Upper gastrointestinal endoscopy and small intestinal biopsies were performed on antibody-positive individuals.
  • Epilepsy types, including generalized, partial, and CPEO, were analyzed.

Main Results:

  • The overall prevalence of CD in children with idiopathic epilepsy was 0.9%.
  • In children with CPEO, the prevalence of CD was significantly higher at 6%.
  • Two out of 33 patients with CPEO tested positive for CD antibodies and showed villous atrophy on biopsy.

Conclusions:

  • Celiac disease prevalence is elevated in children with epilepsy.
  • A notable 6% prevalence of CD in children with CPEO highlights a significant association that requires clinical awareness.
  • Clinicians should consider screening for celiac disease in children presenting with epilepsy, especially CPEO.
Abstract

Keywords:
Celiac Disease; Epilepsy; Occipital Paroxysms

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