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Clinical and Neuroimaging Findings of Sydenham's Chorea

Arzu Ekici1, Ayten Yakut1, Sevgi Yimenicioglu1

  • 1Department of Pediatric Neurology.

Iranian Journal of Pediatrics
|January 7, 2015
PubMed
Abstract

Insights

Sydenham's chorea (SC) in children presents with behavioral changes and weakness. MRI may show white matter abnormalities, suggesting inflammation, but further research is needed to confirm SC pathogenesis.

Area of Science:

  • Neurology
  • Pediatrics
  • Autoimmune Disorders

Background:

  • Sydenham's chorea (SC) is an autoimmune disorder.
  • MRI is crucial for excluding other causes of chorea.
  • Defined MRI features for SC are lacking.

Purpose of the Study:

  • To determine clinical and neuroimaging findings in acute Sydenham's chorea.
  • To investigate the relationship between clinical signs and MRI findings in SC.

Main Methods:

  • Retrospective evaluation of 17 pediatric patients with acute SC.
  • Diagnosis based on the 1992 Jones criteria, excluding other causes.
  • Cranial MRI performed during the acute phase; clinical data collected.

Main Results:

  • Mean patient age was 11.2 years.
  • Common symptoms included behavioral changes (70%), muscle weakness (64%), and dysphagia (23%).
  • Nonspecific white matter hyperintensities observed in 47% of patients, particularly in the caudate nucleus and brain stem.

Conclusions:

  • Nonspecific white matter abnormalities may indicate an inflammatory process in SC.
  • These findings might correlate with the duration of clinical signs.
  • Further comprehensive studies are required to elucidate SC pathogenesis and MRI findings.
Keywords:
Sydenham’s Chorea; MRI Findings; Chorea Paralytica; Corticosteroids

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