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Updated: Apr 18, 2026
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
Published on: June 7, 2016
The SIRT 3 expression profile is associated with pathological and clinical outcomes in human breast cancer patients
Shaozhong He1, Chun He, Hua Yuan
1Departent of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Aims:
To investigate the association of Sirtuin 3 (SIRT 3) expression between the clinical characteristics and prognosis in breast cancer patients.
Methods:
308 female patients with histologically confirmed breast cancer were enrolled in this study. The SIRT 3 expressions in tumor samples were detected. All the patients were followed up overall survival time (OS) and disease-free survival (DFS) time.
Results:
SIRT 3 expression was significantly correlated with clinical characteristics including lymph node metastasis, pathological grade and tumor size of breast cancer. SIRT 3 expression status also affected the DFS and OS of breast cancer. Patients with high expression of SIRT 3 had shorter DFS and OS than those with low expression. Univariate and multivariate Cox analyses confirmed that high SIRT 3 expression predicted a poor prognosis in breast cancer patient. In vitro study revealed that the SIRT 3 knockdown by small interfering RNA technique dramatically reduced the proliferation, migration and invasion of breast cancer cell lines.
Conclusion:
Our results suggest that SIRT 3 may serve as a marker for clinical feature and prognosis for breast cancer.
