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Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
Published on: March 30, 2020
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Advances in cell encapsulation technology and its application in drug delivery
Haritz Gurruchaga1, Laura Saenz del Burgo, Jesús Ciriza
1University of the Basque Country, Laboratory of Pharmacy and Pharmaceutical Technology, NanoBioCel Group, Faculty of Pharmacy, UPV/EHU , Vitoria-Gasteiz, 01006 , Spain.
Expert Opinion on Drug Delivery
|January 8, 2015
Summary
Cell encapsulation technology offers therapeutic advantages by preventing repetitive drug administration. Future clinical use requires optimizing biosafety, biocompatibility, drug delivery control, and scale-up, with cryopreservation being key.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Cell encapsulation technology has advanced significantly over 50 years.
- It offers advantages like preventing repetitive drug administration, enabling diverse therapeutic applications.
Purpose of the Study:
- Summarize improvements in cell encapsulation technology.
- Discuss strategies to overcome clinical application drawbacks.
- Describe studies and clinical trials in various therapeutic areas.
Main Methods:
- Review of advancements in cell encapsulation.
- Analysis of strategies to address limitations.
- Compilation of data from clinical trials.
Main Results:
- Identified key areas for improvement in cell encapsulation.
- Highlighted successful therapeutic applications.
- Discussed challenges hindering clinical translation.
Conclusions:
- Future clinical translation requires optimizing biosafety, biocompatibility, drug delivery, and scale-up.
- Enhancing cryopreservation of encapsulated cells is crucial for clinical accessibility.
- Continued research is needed to bridge the gap from bench to bedside.
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