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Updated: Apr 18, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
[Two pairs of brothers with juvenile idiopathic arthritis (JIA): case reports]
Teresa Cristina M V Robazzi1, Gabriela Rios2, Catarina Castro3
1Serviço de Reumatologia Pediátrica, Universidade Federal da Bahia, Salvador, BA, Brasil; Departamento de Pediatria, Faculdade de Medicina da Universidade Federal da Bahia, Salvador, BA, Brasil.
Abstract:
This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this discovery involves the acknowledgment of major histocompatibility complex (MHC) polymorphism contribution to JIA development susceptibility. Despite many advances, the numerous available studies cannot explain several implicit mechanisms in JIA pathogenesis yet.
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