Related Experiment Video
Updated: Apr 18, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
Novel treatment of allergic fungal sinusitis using omalizumab
Martin Oman Evans1, Christopher Albert Coop
1Department of Internal Medicine, San Antonio Uniformed Services Health Education Consortium.
Abstract:
A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens, increased total serum IgE, increased CD8(+) T-cell prevalence, and IL-4 and IL-5 response. Omalizumab should be considered in the treatment of AFS.
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