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The 'pantie' tumour.
Silada Kanokrungsee1, Vasanop Vachiramon1, Punyaphat Sirithanabadeekul2
1Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Case Reports in Dermatology
|January 8, 2015
Summary
Radiation therapy for endometrial cancer can lead to radiation-associated angiosarcoma years later. Chemotherapy with paclitaxel effectively treated this rare complication, resolving the tumor and symptoms.
Area of Science:
- Oncology
- Dermatology
- Radiation Oncology
Background:
- Endometrium carcinoma is a common gynecologic malignancy.
- Radiation therapy is a standard treatment modality for various cancers, including endometrial cancer.
- Radiation-associated angiosarcoma is a rare but serious complication following radiation treatment.
Observation:
- A 67-year-old Thai woman, previously treated for stage IC endometrium carcinoma with surgery and radiation, developed a pubic mass 10 years later.
- The mass presented in a characteristic "panties" distribution.
- Skin biopsy confirmed the diagnosis of angiosarcoma.
Findings:
- The patient was diagnosed with radiation-associated angiosarcoma.
- The tumor was unresectable, necessitating chemotherapy.
- Treatment with paclitaxel (70 mg/m² every 2 weeks) resulted in significant tumor size reduction and complete symptom resolution after five cycles.
Implications:
- This case highlights the importance of long-term surveillance for rare radiation-induced malignancies.
- Paclitaxel demonstrates efficacy in managing unresectable radiation-associated angiosarcoma.
- Understanding the latency and presentation of radiation-associated angiosarcoma is crucial for timely diagnosis and treatment.