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Control of abnormal synchronization in neurological disorders
Oleksandr V Popovych1, Peter A Tass2
1Institute of Neuroscience and Medicine - Neuromodulation, Jülich Research Center , Jülich , Germany.
Frontiers in Neurology
|January 8, 2015
Summary
This review explores how brain stimulation, like coordinated reset (CR) neuromodulation, can counteract pathological brain synchronization. It highlights model-based therapies using complex systems dynamics to normalize neuronal connectivity and function.
Area of Science:
- Neuroscience
- Complex Systems Dynamics
- Neuromodulation
Background:
- Neuronal synchronization is crucial for brain function but excessive synchronization impairs it, seen in neurological disorders.
- Abnormal synchronization is a hallmark of conditions like Parkinson's disease and tinnitus.
Purpose of the Study:
- To review how invasive and non-invasive brain stimulation can counteract abnormal neuronal synchronization.
- To illustrate model-based therapeutic approaches for normalizing brain function and connectivity.
Main Methods:
- Utilizing insights from synergetics, non-linear dynamics, and statistical physics.
- Applying coordinated reset (CR) neuromodulation as an example of a model-based approach.
- Leveraging spike-timing-dependent plasticity (STDP) to induce multistability in neuronal populations.
Main Results:
- CR neuromodulation exploits the interplay between synaptic connectivity and network dynamics.
- It shifts neuronal populations from synchronized states to desynchronized states with normalized connectivity.
- Therapeutic effects, including normalized synaptic connectivity, can significantly outlast stimulation cessation.
Conclusions:
- Model-based approaches, exemplified by CR neuromodulation, offer novel therapies for neurological disorders characterized by abnormal synchronization.
- These therapies aim to restore physiological patterns of brain connectivity and function.
- Achieving long-lasting therapeutic effects through desynchronization is a key goal.
Keywords:
anti-kindlingcoordinated reset neuromodulationelectrical stimulationneuronal synchronizationnoise stimulationsensory stimulationspike timing-dependent plasticityMore Related Videos
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