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Published on: December 14, 2021
[Pharmacokinetics study of curcumin solid lipid nanoparticles by intravenous injection in rats]
Zi-Jun Yan1, Wan-Yu Li, Li-Li Sun
1Chongqing Key Laboratory of Biochemical and Molecular Pharmacology, Chongqing Medical University, China.
Objective:
To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats.
Methods:
Rats were administrated with (iv) curcumin solid lipid nanoparticles and curcumin solution (8.0 mg/kg), respectively. Blood samples were collected and curcumin in blood plasma was determined by HPLC. Compartmental pharmacokinetics was analyzed by DAS software.
Results:
After intravenous administration, the AUC(0-t), AUC(0-infinity) and t(1/2) of curcumin solid lipid nanoparticles were 1.50-fold, 1.63-fold and 4.08-fold higher than those of curcumin solution as (173.09 ± 44.81) μg x h/L vs. (114.83 ± 13.19) μg x h/L, (196.56 ± 35.25) μg x h/L vs. (120.66 ± 13.95) μg x h/L and (5.95 ± 2.05) h vs. (1.46 ± 0.03) h.
Conclusion:
The curcumin solid lipid nanoparticles is eliminated more slowly. The bioavailability of curcumin in rats increases remarkably compared with that of curcumin solution after intravenous administration.
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