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Updated: Apr 18, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
[Study on preparation of breviscapine liposomes and chemicophysical properties]
Chun Liu1, Cai-Yun Yan, Fei Xiong
1Hainan Institute for Drug Control, Haikou, China.
Objective:
To prepare breviscapine pro-liposomes and evaluate its properties and stability, as well as its interaction with the mimic-membrane.
Methods:
Breviscapine liposomes were prepared by thin film-lyophilization method. Phase inversion temperature was measured by electrical conductance method and coalescence kinetics was studied. Water/n-octanol trans-membrane diffusion model was designed to study the dynamic distribution behavior between two phases, through the determination of diffusion rate of breviscapine and liposomes.
Results:
The phase inversion temperature was 63 degrees C, the activity energy for coalescence was 14.66 kJ/mol. The results suggested that breviscapine from liposomes staying on the interface were found more than the breviscapine infusion.
Conclusion:
Breviscapine liposomes prepared with thin film-lyophilization method have good physicochemical properties and stability, which is beneficial to treatment.
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