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[Optimization of process of sodium aescinate lyophilized powder]
Zhao-Hua Shi1, Li-Jun Chen, Wen-Fang Huang
1Lishizhen Institute of Natural Medicine, Wuhan, China.
Objective:
To determine the optimal freeze-drying process of Sodium Aescinate lyophilized powder in order to shorten the lyophilization cycle.
Methods:
Using the single factor experiment and L9 (3(4)) orthogonal test to optimize parameters of the herbal liquid volume and concentration, pre-freezing time, pressure, drying time and analytical temperature.
Results:
The best lyophilization process parameters were as follows: 1.0 mL herbal liquid with concentration of 10 mg/mL, phased cooling style, pre-freezing temperature at - 35 degrees C, 6.5 h; vacuum of 20 Pa;sublimation drying time of 7 h; and desorption-drying temperature of 35 degrees C for 5.5 h.
Conclusion:
Compared with the original process conditions, the product quality is more stable and the freezing-drying cycle time is shorten of 3 h, which can provide technical reference for production process of the freeze-dried powder of sodium aescinate.
