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Related Experiment Videos

Artefacts associated with a cryoglobulin.

H Hambley1, J M Vetters

  • 1Department of Haematology, Regina General Hospital, Saskatchewan, Canada.

Postgraduate Medical Journal
|April 1, 1989
PubMed
Summary

Cryoglobulin presence in a 70-year-old man led to unusual lab results, including pseudoleukocytosis and rare intracytoplasmic inclusions. The study details these unique cryoglobulin-induced laboratory anomalies.

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Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Cryoglobulinemia can manifest with diverse clinical and laboratory findings.
  • Prompt recognition of cryoglobulin-induced laboratory abnormalities is crucial for accurate diagnosis and management.

Observation:

  • A 70-year-old male patient presented with several unusual laboratory findings.
  • These anomalies were initially not attributed to cryoglobulin presence.

Findings:

  • The patient exhibited pseudoleukocytosis, a known but uncommon laboratory artifact.
  • Rare intracytoplasmic inclusion bodies were observed within blood cells.
  • A unique and previously undescribed alteration in the erythrocyte sedimentation rate (ESR) was noted.

Implications:

  • This case highlights the importance of considering cryoglobulinemia in the differential diagnosis of unexplained laboratory abnormalities.
  • The rare intracytoplasmic inclusions and novel ESR changes expand the known spectrum of cryoglobulin-related laboratory phenomena.
  • Further research into cryoglobulin-induced laboratory alterations may improve diagnostic strategies.

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