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Related Experiment Videos

Enalapril-induced cough.

G R Gibson1

  • 1Department of Medicine, Northeastern Ohio Universities College of Medicine, Rootstown.

Archives of Internal Medicine
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

Enalapril maleate can cause a persistent, dry cough in about 10.5% of patients, particularly women. This enalapril-induced cough is reversible upon discontinuing the medication.

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Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Respiratory Medicine

Background:

  • Enalapril maleate is a widely prescribed medication for hypertension and heart failure.
  • A significant side effect of enalapril therapy is an intractable cough.
  • Understanding the incidence and characteristics of this cough is crucial for patient management.

Purpose of the Study:

  • To determine the incidence and clinical features of cough associated with enalapril maleate use.
  • To identify patient characteristics and factors influencing the development of enalapril-induced cough.
  • To differentiate enalapril-induced cough from other causes of persistent cough.

Main Methods:

  • Retrospective analysis of medical records from an outpatient practice.
  • Inclusion of 209 patients undergoing enalapril therapy.

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  • Evaluation of cough incidence, patient demographics, and treatment outcomes.

    • Main Results:

    • 22 out of 209 patients (10.5%) discontinued enalapril due to intractable dry cough.
    • Cough was more prevalent in women (14.6%) compared to men (6%).
    • Cough resolved within two weeks of enalapril discontinuation in 21 patients; no significant differences in age, smoking, or comorbidities were found between patients with and without cough.

    Conclusions:

    • Enalapril-induced cough is a common, benign, and reversible side effect.
    • Increased clinical awareness is necessary to distinguish it from other respiratory conditions.
    • Discontinuation of enalapril is effective in resolving the cough in most affected patients.