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Bioaccessibility of Difenoconazole in Rice Following Industry Standard Processing and Preparation Procedures.

M Craggs¹, G R Gibson², P Whalley¹

¹Product Safety, Jealott's Hill International Research Centre, Syngenta International AG, Bracknell, Berkshire RG42 6EY, United Kingdom.

Journal of Agricultural and Food Chemistry

|August 14, 2020

Summary

This summary is machine-generated.

Pesticide residue safety assessments often ignore bioaccessibility. This study found that processing impacts difenoconazole residue bioaccessibility in rice, with mechanical methods increasing it and chemical methods decreasing it.

Keywords:

human exposure ingestion microbial degradation pesticide registration risk assessment

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Area of Science:

Food chemistry
Environmental toxicology
Analytical chemistry

Background:

Pesticide residue safety assessments typically do not account for residue bioaccessibility.
Bioaccessibility is crucial for accurately assessing human exposure to pesticide residues.
In vitro simulated gut systems offer a more reliable method for determining bioaccessibility compared to solvent extraction.

Purpose of the Study:

To investigate the bioaccessibility of difenoconazole residues in processed rice.
To evaluate the impact of different commodity processing methods on residue bioaccessibility.
To refine the risk assessment process for pesticide residues.

Main Methods:

Utilized in vitro intestinal extraction and colonic fermentation models to simulate human digestion.
Assessed the bioaccessibility of difenoconazole residues in processed rice samples.
Quantified residue levels and bioaccessible fractions using analytical chemistry techniques.

Main Results:

The mean bioaccessibility of difenoconazole following intestinal digestion was 33.3% (range: 13%–70.6%).
Mechanical processing generally increased residue bioaccessibility, while chemical processing decreased it.
Both mechanical and chemical processing methods reduced total difenoconazole residue levels by approximately 50%.

Conclusions:

Commodity processing significantly influences the bioaccessibility of difenoconazole residues in rice.
In vitro digestion models provide valuable insights into potential human exposure to pesticide residues.
Further research is needed to quantify colonic bioaccessibility due to compound metabolism.