Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.2K
Reticular Dermis01:15

Reticular Dermis

5.6K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
5.6K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.3K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.3K
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

3.5K
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
3.5K
Muscles for Facial Expressions01:14

Muscles for Facial Expressions

6.3K
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
6.3K
Layers of the Epidermis01:21

Layers of the Epidermis

11.4K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Vernix caseosa reveals mechanistic clues linking maternal obesity to atopic dermatitis pathogenesis.

The Journal of allergy and clinical immunology·2023
Same author

Color Doppler Ultrasound Assessment of Subclinical Activity With Scoring of Morphea.

Journal of cutaneous medicine and surgery·2023
Same author

Erythrasma and the role of Wood's light: A simple diagnosis pearl.

Medicina clinica·2023
Same author

Ultrasound Morphea Activity Scoring (US-MAS): Modified US-MAS.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine·2023
Same author

Classic Physical Exam Findings in Ehlers-Danlos Syndrome.

Journal of general internal medicine·2023

Related Experiment Video

Updated: Apr 18, 2026

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.7K

Wrinkles.

Juan Jorge Manríquez1, Karina Cataldo, Cristián Vera-Kellet

  • 1Departamento de Dermatologia, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.

BMJ Clinical Evidence
|January 9, 2015
PubMed
Summary

This systematic review evaluated treatments for skin wrinkles caused by photodamage and aging. It found 33 studies on interventions like botulinum toxin, lasers, and chemical peels, assessing their effectiveness and safety.

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Evidence-Based Medicine

Background:

  • Photodamage from UV light causes skin issues like wrinkles, hyperpigmentation, and roughness, particularly in lighter skin types.
  • Wrinkles are also linked to aging, hormones, smoking, and other health conditions.

Purpose of the Study:

  • To systematically review and evaluate the effects of various treatments for skin wrinkles.
  • To assess the effectiveness and safety of different interventions for wrinkle reduction.

Main Methods:

  • Systematic review of literature up to February 2014, searching major medical databases.
  • Inclusion of 33 studies meeting predefined criteria.
  • GRADE evaluation of the quality of evidence for each intervention.

More Related Videos

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

915
Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
04:30

Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis

Published on: January 17, 2025

2.5K

Related Experiment Videos

Last Updated: Apr 18, 2026

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.7K
Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

915
Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
04:30

Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis

Published on: January 17, 2025

2.5K

Main Results:

  • A comprehensive review of 33 studies was conducted.
  • The quality of evidence for various interventions was assessed using the GRADE system.

Conclusions:

  • The review presents findings on the effectiveness and safety of botulinum toxin injections, carbon dioxide laser, chemical peels, dermabrasion, isotretinoin, tazarotene, tretinoin, and variable pulse erbium:YAG laser.
  • This information aids in understanding treatment options for skin wrinkles.