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Distributed feedback laser for biosensing applications.

A-M Haughey, B Guilhabert, M D Dawson

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|January 9, 2015

Summary

This summary is machine-generated.

We developed an organic semiconductor laser biosensor for detecting substances. This device shows potential for sensitive, repeatable measurements and optimization for refractive index changes.

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Area of Science:

* Organic electronics
* Photonics
* Biosensing technologies

Background:

* Existing biosensors face limitations in sensitivity and reusability.
* Organic semiconductor lasers offer tunable optical properties for sensing applications.

Purpose of the Study:

* To develop and characterize an organic semiconductor distributed feedback laser biosensor.
* To optimize the biosensor for detecting refractive index changes.
* To demonstrate the biosensor's capability in a specific biomolecular assay.

Main Methods:

* Fabrication of an organic semiconductor distributed feedback laser.
* Optimization of the gain layer thickness for maximal response to refractive index variations.
* Performance evaluation using bulk sensing and a desthiobiotin-avidin assay.

Main Results:

* Demonstrated successful operation of the organic semiconductor laser biosensor.
* Optimized gain layer thickness enhanced sensitivity to refractive index changes.
* The desthiobiotin-avidin assay showed the potential for specific molecular detection.
* Repeated sensing measurements were successfully performed, indicating reusability.

Conclusions:

* The organic semiconductor distributed feedback laser biosensor is a viable platform for sensitive detection.
* The device shows promise for label-free, repeatable biosensing applications.
* Further optimization could lead to advanced diagnostic tools.