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A Method for Growing Bio-memristors from Slime Mold
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Development and initial testing of a novel slime mould biosensor.

James G H Whiting, Ben de Lacy Costello, Andrew Adamatzky

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 9, 2015
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    This study introduces a novel whole cell biosensor using the slime mould Physarum polycephalum (PP). This biosensor can detect and identify various chemicals by measuring changes in its electrical response, offering potential for environmental monitoring.

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    Area of Science:

    • Biotechnology
    • Biosensor Development
    • Cellular Electrophysiology

    Background:

    • Whole cell biosensors utilize cellular components or whole cells for analyte detection.
    • Existing biosensors employ diverse cell types for specific interactions.
    • The slime mould Physarum polycephalum (PP) has not been previously explored for biosensing applications.

    Purpose of the Study:

    • To develop and characterize a novel whole cell biosensor utilizing the slime mould Physarum polycephalum (PP).
    • To quantify the electrical response of PP to various chemical stimuli.
    • To assess the potential of the PP biosensor for chemical detection and identification.

    Main Methods:

    • Exposure of Physarum polycephalum (PP) to a range of chemicals.
    • Measurement and quantification of PP's electrical response, focusing on amplitude and frequency shifts.
    • Analysis of specific changes in oscillation frequency and amplitude for chemical identification.

    Main Results:

    • The PP biosensor successfully detected and identified multiple tested chemicals.
    • Specific shifts in oscillation amplitude and frequency correlated with individual chemical presence.
    • Environmental factors like light and temperature influenced PP's electrical response, indicating potential for broader sensing capabilities.

    Conclusions:

    • The novel Physarum polycephalum (PP) whole cell biosensor demonstrates efficacy in detecting and identifying various chemicals.
    • The biosensor's sensitivity to environmental factors presents both challenges and opportunities for expanded applications.
    • This research proposes the PP biosensor as a valuable tool for environmental monitoring and toxicity evaluation of organic chemicals.