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Updated: Apr 18, 2026

Fabrication of Three-Dimensional Graphene-Based Polyhedrons via Origami-Like Self-Folding
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Three-dimensional, flexible graphene bioelectronics.

SungGyu Chun, Jonghyun Choi, Ali Ashraf

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 9, 2015
    PubMed
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    Researchers developed flexible 3D graphene biosensors using a novel transfer method. This all-carbon structure offers potential for advanced biological interfacing and intracellular recording in future applications.

    Area of Science:

    • Materials Science
    • Nanotechnology
    • Biomedical Engineering

    Background:

    • Graphene's unique properties make it suitable for biosensing applications.
    • Existing methods for fabricating 3D graphene structures face challenges like delamination and limited conformability.
    • Developing mechanically flexible, 3D graphene biosensors is crucial for advanced biological interfacing.

    Purpose of the Study:

    • To report the fabrication of 3-dimensional (3D) graphene-based biosensors.
    • To demonstrate a novel 3D transfer method for monolithic graphene-graphite structures.
    • To explore the potential of these structures for intimate 3D biological interfacing.

    Main Methods:

    • Synthesized monolithic graphene-graphite structures using low-pressure chemical vapor deposition (LPCVD) with heterostructured metal catalysts.

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  • Employed nonplanar substrates and a wet-transfer method with a gold (Au) film as a transfer layer.
  • Utilized vapor-phase etching to remove the transfer layer, minimizing graphene delamination.

    • Main Results:

    • Successfully fabricated mechanically flexible, all-carbon 3D graphene-graphite structures.
    • Achieved conformal 3D transfer of graphene onto nonplanar substrates.
    • Demonstrated a method to minimize graphene delamination during transfer layer removal.

    Conclusions:

    • The developed 3D graphene-graphite structures are promising for intimate 3D interfacing with biological systems.
    • The combination of monolithic synthesis and conformal 3D transfer enables 3D conformal sensing capabilities.
    • This approach holds potential for future intracellular recording applications in living cells.