Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Integration of Synaptic Events01:28

Integration of Synaptic Events

6.5K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
6.5K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

4.3K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
4.3K
Neural Circuits01:25

Neural Circuits

3.4K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.4K
Electrical Synapses01:28

Electrical Synapses

12.2K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
12.2K
Non-gated Ion Channels01:24

Non-gated Ion Channels

9.2K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
9.2K
Resting Potential Decay01:15

Resting Potential Decay

7.0K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytomegalovirus enteritis in a patient with AKI after type B aortic dissection surgery: a case report.

BMC infectious diseases·2026
Same author

Effects of HFPO-DA (GenX) exposure on placental glycolysis and metabolic microenvironment in pregnant rats.

Toxicology·2026
Same author

Dynamic stability-activity profiling of traditional Chinese medicine: Decoding functional substances through forced degradation characteristics using Guizhi Fuling capsules as a demonstration.

Fitoterapia·2026
Same author

Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Combining plasma biomarkers and cognitive challenge tests enhances prediction of functional trajectories of decline among older adults with cognitive impairment.

Journal of Alzheimer's disease : JAD·2026
Same author

Study on the analgesic and anti-inflammatory mechanisms of Jingu Zhitong gel in the treatment of knee osteoarthritis through the IL-17, NGF-TrkA, and COX-2/PGE2 pathways.

Frontiers in pharmacology·2026

Related Experiment Video

Updated: Apr 18, 2026

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

12.2K

A biological plausible Generalized Leaky Integrate-and-Fire neuron model.

Zhenzhong Wang, Lilin Guo, Malek Adjouadi

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 9, 2015
    PubMed
    Summary

    A new Generalized Leaky Integrate-and-Fire (GLIF) neuron model offers improved accuracy by incorporating a variable leaking resistor and bias current. This adaptable model can precisely replicate Hodgkin-Huxley (HH) model behaviors for realistic neuron simulations.

    More Related Videos

    Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
    08:04

    Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

    Published on: June 6, 2025

    1.8K
    Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
    08:34

    Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

    Published on: May 9, 2021

    3.2K

    Related Experiment Videos

    Last Updated: Apr 18, 2026

    Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
    08:08

    Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

    Published on: June 24, 2015

    12.2K
    Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
    08:04

    Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

    Published on: June 6, 2025

    1.8K
    Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
    08:34

    Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

    Published on: May 9, 2021

    3.2K

    Area of Science:

    • Computational neuroscience
    • Biophysics
    • Neural modeling

    Background:

    • Traditional Leaky Integrate-and-Fire (NLIF) models offer a simplified approach to neuronal dynamics.
    • Accurate modeling of biological neuron behavior is crucial for understanding neural computation.
    • Existing models may lack the flexibility to capture the full range of neuronal responses.

    Purpose of the Study:

    • Introduce a novel Generalized Leaky Integrate-and-Fire (GLIF) neuron model.
    • Enhance the accuracy and biological plausibility of integrate-and-fire neuron models.
    • Provide a computationally efficient alternative to complex biophysical neuron models.

    Main Methods:

    • Developed a new GLIF neuron model incorporating a variable leaking resistor.
    • Introduced an additional bias current term into the model equation.
    • Validated the GLIF model by matching its parameters to Hodgkin-Huxley (HH) models.

    Main Results:

    • The GLIF model demonstrates improved accuracy compared to standard NLIF models.
    • Adjustable parameters allow the GLIF model to closely approximate HH model dynamics.
    • The GLIF model successfully reproduces plausible biological neuron behaviors.

    Conclusions:

    • The GLIF model offers a significant advancement in neuronal modeling.
    • Its adaptability makes it suitable for simulating diverse neuron types and behaviors.
    • This model provides a powerful tool for neuroscience research and simulations.