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Updated: Apr 18, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse
Published on: November 17, 2009
Bilateral Dentate Gyrus Structural Alterations in a Cat Associated With Hippocampal Sclerosis and Intraventricular
A Klang1, D Thaller2, P Schmidt1
1Institute of Pathology and Forensic Veterinary Medicine, Department for Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Abstract:
A 13-year-old cat had a history of seizures for 3 years that resembled temporal lobe epilepsy. Histologic examination of the brain revealed bilateral hippocampal alterations, including hypergyration and broadening of the dentate gyrus associated with hippocampal sclerosis and an intraventricular meningioma near the hippocampal region. The findings in the dentate gyrus were interpreted as a congenital malformation; however, it could not be ruled out that the alterations were induced by the seizures. Similar changes of the dentate gyrus have not been previously described in cats.

