Distinct intrinsic network connectivity patterns of post-traumatic stress disorder symptom clusters
M Tursich1, T Ros2, P A Frewen1,3,4
1Department of Psychiatry, The University of Western Ontario, London, ON, Canada.
Acta Psychiatrica Scandinavica
|January 10, 2015
Summary
This study reveals distinct brain network connectivity patterns associated with post-traumatic stress disorder (PTSD) symptom dimensions. Findings suggest potential biomarkers for PTSD and its dissociative subtype.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Post-traumatic stress disorder (PTSD) is a complex condition with multiple symptom clusters.
- Previous research indicates disruptions in intrinsic brain network connectivity in PTSD.
- The specific network connectivity patterns underlying different PTSD symptom dimensions remain incompletely understood.
Purpose of the Study:
- To investigate the association between resting-state functional connectivity of the salience network (SN), default mode network (DMN), and central executive network (CEN) and PTSD symptom severity.
- To explore how connectivity within and between these networks relates to specific PTSD symptom clusters: re-experiencing, avoidance/numbing, hyperarousal, and depersonalization/derealization.
Main Methods:
- Utilized resting-state functional MRI data from 21 participants diagnosed with PTSD.
- Applied multivariate analyses to examine how intrinsic network connectivity, derived from independent components, correlates with PTSD symptom severity.
- Focused on connectivity within the SN, DMN, and CEN.
Main Results:
- Hyperarousal symptoms correlated with reduced SN connectivity in the posterior insula/superior temporal gyrus.
- Depersonalization/derealization severity was linked to decreased connectivity in the perigenual anterior cingulate/ventromedial prefrontal cortex within the ventral anterior DMN.
- Altered synchrony was observed between DMN components and between the DMN and CEN in relation to symptom severity.
Conclusions:
- The findings support the notion of heterogeneous intrinsic network connectivity patterns underlying distinct PTSD symptom dimensions.
- These network disruptions offer potential neurobiological markers for PTSD, including its dissociative subtype.
- The study highlights the importance of examining network connectivity in relation to specific symptom clusters for a more nuanced understanding of PTSD.
Keywords:
adult survivors of child abusefunctional neuroimagingmultivariate analysispost-traumatic stress disordersMore Related Videos
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