Diffusion model to describe osteogenesis within a porous titanium scaffold
M Schmitt1, R Allena1, T Schouman1,2
1a Arts et Métiers ParisTech, LBM , 151 bd de l'hôpital, 75013 Paris , France.
Abstract:
In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 weeks. The cell activity is described through diffusion equations and regulated by the stress state of the structure. We compare our model to (i) histological observations and (ii) experimental data obtained from a mechanical test done on sacrificed animal. We show that our mechano-biological approach provides consistent numerical results and constitutes a useful tool to predict osteogenesis pattern.
More Related Videos
Related Concept Videos
Bone Formation by Endochondral Ossification
Spongy Bone
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Remodeling
The Bone Matrix
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
Growth of Cartilage and Bone Tissue


