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Acquire: an open-source comprehensive cancer biobanking system.

Heidi Dowst1, Benjamin Pew1, Chris Watkins1

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A new open-source system, Acquire, streamlines cancer biobank data management. It enhances specimen tracking, quality control, and resource sharing for targeted cancer therapy research.

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Area of Science:

  • Biobanking
  • Genomic Medicine
  • Translational Research

Background:

  • Targeted cancer therapies require precise patient stratification based on genetic mutations.
  • Human cancer biobanks are crucial for providing resources like patient-derived xenografts (PDX) and cell lines for translational research.
  • Effective management of complex biobank data and workflows is essential to support these research endeavors.

Purpose of the Study:

  • To develop a comprehensive system for managing the data and workflows of modern cancer biobanks.
  • To enhance the integration of biobanks with genomic sequencing and derivative generation facilities.
  • To provide a robust platform supporting various biobank operations and research needs.

Main Methods:

  • Development of Acquire, a secure, web-based, database-backed, open-source system.
  • Implementation of modules for collection reporting, user management, specimen inventory (via caTissue Suite), and shipping.
  • Integration of features for quality control metrics, researcher requests, and resource allocation oversight.

Main Results:

  • Acquire provides real-time reporting and graphical overviews of biobank collections.
  • The system facilitates secure specimen inventory management and distribution tracking.
  • Acquire supports robust querying, quality control monitoring, and linkage to specimen derivatives.

Conclusions:

  • Acquire is a versatile, open-source solution addressing the complex data management needs of cancer biobanks.
  • The system enhances operational efficiency, data security, and resource accessibility for translational cancer research.
  • Acquire supports the critical link between biobanking, genomic analysis, and the development of targeted therapeutics.