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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Related Experiment Video

Updated: Dec 26, 2025

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Polyarticular Clostridium perfringens pyoarthritis.

G Lluberas-Acosta1, R Elkus, H R Schumacher

  • 1Frankford Hospital, University of Pennsylvania School of Medicine, Philadelphia 19104.

The Journal of Rheumatology
|November 1, 1989
PubMed
Summary

This case report details a rare instance of Clostridium perfringens causing septic arthritis in multiple joints. The patient also had an abdominal mass, complicating diagnosis.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Clinical Case Study

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting joints.
  • Septic arthritis is a joint infection that can rapidly destroy cartilage.
  • Clostridium perfringens is a bacterium rarely implicated in septic arthritis.

Observation:

  • A patient with rheumatoid arthritis presented with an abdominal mass.
  • The patient developed septic arthritis affecting both wrists and shoulders.
  • Joint effusions contained apatite, lipid, and cholesterol crystals.

Findings:

  • This is the first reported case of polyarticular septic arthritis caused by Clostridium perfringens.
  • The abdominal mass may have been associated with the septic arthritis.

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  • Crystal presence in joint effusions caused diagnostic challenges.

    • Implications:

    • Highlights the importance of considering rare pathogens in septic arthritis, especially in immunocompromised patients.
    • Suggests a potential link between abdominal pathology and Clostridium perfringens septic arthritis.
    • Emphasizes the need for thorough diagnostic evaluation to differentiate crystal arthropathy from infection.