Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

132
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
132
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

108
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
108
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

146
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
146
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

290
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
290

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emission of Photons by Near-Infrared PbS Quantum Dot Nanocrystals for a Large Diameter Range.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Polyurethane Depolymerization With Alkyl, Aryl, and Mixed Carbonates.

ChemSusChem·2026
Same author

Automated Generation of Supported Lipid Bilayer Arrays with Controlled Receptor Densities in Well Plates.

ACS applied materials & interfaces·2026
Same author

The stem of <i>Schisandra chinensis</i> and Schisandrin B alleviated DNCB-induced atopic dermatitis in mice by inhibiting the NF-κB pathway.

Frontiers in immunology·2026
Same author

Material-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides.

ACS omega·2025
Same author

Kynurenine 3-hydroxylase Inhibitor RO 61-8048 Alleviates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice.

Journal of biochemical and molecular toxicology·2025
Same journal

Bi-modified Ni<sub>3</sub>S<sub>2</sub> promotes selective nitrite-to-hydroxylamine reduction for cyclohexanone oxime synthesis.

Chemical communications (Cambridge, England)·2026
Same journal

Cyclable manganese inventory as a mechanistic descriptor for electrolyte design in rechargeable aqueous Zn-MnO<sub>2</sub> batteries.

Chemical communications (Cambridge, England)·2026
Same journal

Cobalt-iron layered double hydroxides with ligand modification for boosting glycerol electrooxidation-assisted hydrogen production.

Chemical communications (Cambridge, England)·2026
Same journal

Beyond the vacuum: modeling the solid-liquid interface for gas-involving electrocatalysis.

Chemical communications (Cambridge, England)·2026
Same journal

Alkaline-earth carbonate-supported Ru for quinoline hydrogenation: enhanced H<sub>2</sub> activation <i>via</i> electronic metal-support interaction.

Chemical communications (Cambridge, England)·2026
Same journal

Mitigating ionic conductivity limitations <i>in operando</i> electrochemical X-ray photoelectron spectroscopy.

Chemical communications (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

10.9K

Bi-compartmental responsive polymer particles.

Jiguang Liu1, Jurriaan Huskens

  • 1Molecular Nanofabrication group, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. Jiguangl@iccas.ac.cn j.huskens@utwente.nl.

Chemical Communications (Cambridge, England)
|January 10, 2015
PubMed
Summary
This summary is machine-generated.

Researchers developed novel bi-compartmental copolymer particles with distinct poly(acrylic acid) and poly(N,N-isopropylacrylamide) regions. These adaptable particles change shape and properties, offering control over emulsification based on pH levels.

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.5K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.6K

Related Experiment Videos

Last Updated: Apr 18, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

10.9K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

10.5K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

38.6K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Developing advanced copolymer particles is crucial for tailored material properties.
  • Controlling phase separation during synthesis enables unique particle architectures.

Purpose of the Study:

  • To synthesize novel bi-compartmental copolymer particles in a single reaction.
  • To investigate the tunable properties and applications of these particles.

Main Methods:

  • One-pot synthesis controlling polymerization-induced phase separation.
  • Characterization of particle morphology and composition.
  • Assessment of swelling behavior and surface deposition.

Main Results:

  • Successfully synthesized bi-compartmental particles with poly(acrylic acid) and poly(N,N'-isopropylacrylamide) domains.
  • Demonstrated pH-dependent swelling and surface deposition capabilities.
  • Utilized particles for pH-controlled emulsification.

Conclusions:

  • The novel synthesis method yields versatile bi-compartmental particles.
  • These particles offer tunable properties for advanced applications.
  • Potential use in emulsion stabilization and surface modification.