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Corneal Donor Tissue Preparation for Endothelial Keratoplasty
Published on: June 12, 2012
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[DSAEK after failed penetrating keratoplasty].
K Zitte1, N Bonnin2, J-L Kémény3
1RMND-M2O Pole, Ophthalmology department, Clermont-Ferrand University Hospital, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
Journal Francais D'Ophtalmologie
|January 11, 2015
Summary
Descemet stripping automated endothelial keratoplasty (DSAEK) offers a viable option for eyes with failed penetrating keratoplasty (PK), achieving good graft survival and visual improvement. However, outcomes can be limited by patient comorbidities.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Regenerative Medicine
Background:
- Penetrating keratoplasty (PK) is a common treatment for corneal failure.
- Endothelial decompensation following PK can necessitate repeat transplantation.
- Descemet stripping automated endothelial keratoplasty (DSAEK) is an alternative endothelial keratoplasty technique.
Purpose of the Study:
- To evaluate the anatomic and functional outcomes of DSAEK in eyes with prior failed PK.
- To assess graft survival rates and visual acuity improvements after DSAEK in this specific patient cohort.
Main Methods:
- Retrospective, single-center observational study.
- 32 eyes of 26 patients with failed PK grafts underwent DSAEK.
- Outcomes included graft survival, best-corrected visual acuity (BCVA), and complications.
Main Results:
- Graft survival at 12 months was 76.1%.
- Mean BCVA improved significantly from 1.48 logMAR to 0.996 logMAR at 6 months.
- Early graft detachment/decentration occurred in 8 eyes, with 3 requiring repeat DSAEK and 3 conversion to PK.
Conclusions:
- DSAEK demonstrates comparable anatomic outcomes to other studies for failed PK.
- Visual recovery is rapid due to preserved anterior corneal curvature.
- Comorbid conditions can limit final BCVA, highlighting the need for personalized surgical strategies.
