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[Brain abscess caused by Haemophilus influenzae type E in a pediatric patient suffering from Apert syndrome]

Adela M Isasmendi1, José L Pinheiro1, Natalia García Escudé2

  • 1Servicio de Microbiología, Hospital de Pediatría Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.

Revista Argentina De Microbiologia
|January 11, 2015
PubMed

Insights

A rare brain abscess caused by Haemophilus influenzae type e occurred in a 12-year-old with Apert syndrome. Prompt diagnosis and treatment led to a full recovery.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Genetics

Background:

  • Apert syndrome, a genetic disorder, involves premature cranial suture fusion.
  • Patients with Apert syndrome may have increased susceptibility to infections.
  • Previous head trauma and cerebrospinal fluid fistula can predispose to brain abscess.

Observation:

  • A 12-year-old male with Apert syndrome presented with fever, seizures, and altered mental status.
  • Imaging revealed a right frontal brain abscess with associated edema and pansinusitis.
  • Cerebrospinal fluid fistula secondary to prior trauma was noted.

Findings:

  • Cultures identified Haemophilus influenzae serotype e as the causative agent.
  • Initial empirical treatment included meropenem and vancomycin.
  • Treatment was adjusted to ceftriaxone and metronidazole based on culture results.

Implications:

  • This case highlights a rare presentation of Haemophilus influenzae type e brain abscess in a patient with Apert syndrome.
  • Early surgical drainage and appropriate antibiotic therapy are crucial for favorable outcomes.
  • Understanding the interplay between genetic predisposition, trauma, and infection is vital for managing complex neurological cases.

Keywords:
Absceso cerebralApert syndromeBrain abscessHaemophilus influenzaeSíndrome de Aper

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