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Related Concept Videos

Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Amyloidosis in Behcet's disease.

I Ben Ghorbel1, Nabil Belfeki, T Ben Salem

  • 1Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|January 13, 2015
PubMed
Summary
This summary is machine-generated.

Behcet's disease (BD) associated with amyloidosis leads to nephrotic syndrome. This complication has a high mortality rate, even with aggressive immunosuppressive treatments.

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Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Background:

  • Behcet's disease (BD) is a complex multisystem vasculitis.
  • The underlying causes of BD's persistent inflammation remain unclear.
  • Amyloidosis is a potential complication of chronic inflammatory conditions.

Observation:

  • This study reports cases of Behcet's disease complicated by secondary amyloidosis.
  • Patients presented with nephrotic syndrome as a direct result of amyloidosis.
  • The amyloidosis observed was resistant to standard immunosuppressive therapies.

Findings:

  • Secondary amyloidosis in Behcet's disease can manifest as severe nephrotic syndrome.
  • Treatment with immunosuppressive agents was ineffective in resolving the amyloidosis.
  • The complication of amyloidosis significantly increases mortality risk in Behcet's disease patients.

Implications:

  • Behcet's disease with amyloidosis carries a poor prognosis.
  • Current aggressive therapies may not be sufficient for managing this complication.
  • Further research is needed to understand and treat BD-associated amyloidosis effectively.