Multi-site cyclization via initial C-H activation using a rhodium(III) catalyst: rapid assembly of frameworks
Ji-Rong Huang1, Liu Qin, Yu-Qin Zhu
1Key laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. dongl@scu.edu.cn.
Abstract:
Tandem multi-site cyclization triggered by Rh(iii)-catalyzed C-H activation has been achieved for highly efficient synthesis of spirocycle indolin-3-one (C2-cyclization), benzo[a]carbazole (C3-cyclization) and an unusual indoxyl core (N1-cyclization). In particular, the synthesis of pseudo-indoxyl is typically completed within 10 min, and the reaction tolerates air, water and a range of solvents.
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