Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.3K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.3K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

375
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
375
Dementia l: Introduction01:22

Dementia l: Introduction

1
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
1
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

2
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
2
Long-term Depression01:03

Long-term Depression

3.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Indiana University Brain Health Program to deliver amyloid-targeted therapy to Alzheimer's disease patients.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

Phase 1 trial of pre-operative image guided intensity modulated photon radiotherapy with simultaneously integrated boost to the high-risk margin for patients with retroperitoneal sarcoma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Semaglutide and Neovascular Age-Related Macular Degeneration Among Adults with Type 2 Diabetes: An OHDSI Network Study.

Ophthalmology·2026
Same author

Olutasidenib as maintenance therapy after treatment response in acute myeloid leukemia with persistent <i>IDH1</i> mutation.

Blood neoplasia·2026
Same author

Patient Digital Engagement With After Visit Summary in Ambulatory Care.

JAMA network open·2026
Same author

A Pile of Books.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Related Experiment Video

Updated: Apr 18, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

8.0K

Depression and cognition in the elderly.

Sophia Wang1, Dan G Blazer

  • 1Department of Psychiatry and Behavior Sciences, Duke University Medical Center, Durham, North Carolina 27710; email: swang6@gmail.com , dan.g.blazer@duke.edu.

Annual Review of Clinical Psychology
|January 13, 2015
PubMed
Summary
This summary is machine-generated.

This review explores the link between elderly depression and cognitive decline, focusing on non-drug treatments like psychotherapy. It highlights evidence for cognitive and functional benefits of these approaches in older adults.

Keywords:
antidepressantsbrain stimulation therapiesmajor depressive disordermild cognitive impairmentneurocognitive disorderneuroimagingneuropsychological testingpsychotherapy

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.7K

Related Experiment Videos

Last Updated: Apr 18, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

8.0K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.7K

Area of Science:

  • Gerontology
  • Neuroscience
  • Psychiatry

Background:

  • Late-life depression frequently co-occurs with cognitive impairment.
  • Understanding the epidemiology and risk factors for cognitive decline in elderly individuals with depression is crucial.
  • The temporal relationship between depression onset and cognitive impairment requires further elucidation.

Purpose of the Study:

  • To review the relationship between depression and cognition in the elderly.
  • To emphasize psychotherapies and nonpharmacologic treatments for late-life depression with cognitive impairment.
  • To examine the cognitive and functional benefits of these interventions.

Main Methods:

  • Comprehensive literature review focusing on depression, cognition, and nonpharmacologic interventions in older adults.
  • Analysis of clinical presentation, epidemiology, risk factors, and suicide in late-life depression with cognitive impairment.
  • Evaluation of evidence for psychotherapies, nontraditional treatments, pharmacologic therapies, and brain stimulation.

Main Results:

  • Psychotherapies and nonpharmacologic approaches show promise for improving cognitive and functional outcomes in elderly individuals with depression.
  • Pharmacologic treatments and brain stimulation therapies also have cognitive effects that warrant consideration.
  • Neuropsychological deficits, biomarkers, and neuroimaging findings are associated with comorbid cognitive impairment in late-life depression.

Conclusions:

  • Nonpharmacologic interventions, including psychotherapy, are valuable for managing cognitive impairment in elderly patients with depression.
  • A multifaceted approach combining psychological, nonpharmacologic, and potentially pharmacologic strategies may be most effective.
  • Further research is needed to fully understand the efficacy and mechanisms of various treatments for late-life depression and cognitive decline.